Prospective Multicenter Evaluation of the Direct Flow Medical Transcatheter Aortic Valve
Identifieur interne : 000427 ( Main/Exploration ); précédent : 000426; suivant : 000428Prospective Multicenter Evaluation of the Direct Flow Medical Transcatheter Aortic Valve
Auteurs : Joachim Schofer [Allemagne] ; Antonio Colombo [Italie] ; Silvio Klugmann [Italie] ; Jean Fajadet [France] ; Federico Demarco [Italie] ; Didier Tchetche [France] ; Francesco Maisano [Italie] ; Giuseppe Bruschi [Italie] ; Azeem Latib [Italie] ; Klaudija Bijuklic [Allemagne] ; Neil Weissman [États-Unis] ; Reginald Low [États-Unis, Royaume-Uni] ; Martyn Thomas [Royaume-Uni] ; Christopher Young [Royaume-Uni] ; Simon Redwood [Royaume-Uni] ; Michael Mullen [Allemagne] ; John Yap [Allemagne] ; Eberhard Grube [Allemagne] ; Georg Nickenig [Allemagne] ; Jan-Malte Sinning [Allemagne] ; Karl Eugen Hauptmann [Allemagne] ; Ivar Friedrich [Allemagne] ; Michael Lauterbach [Allemagne] ; Michael Schmoeckel [États-Unis] ; Charles Davidson [France] ; Thierry Lefevre [États-Unis]Source :
- Journal of the American College of Cardiology [ 0735-1097 ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Prospective, Médecine.
English descriptors
- KwdEn :
Abstract
Objectives The study sought a prospective multicenter nonrandomized evaluation of the Direct Flow Medical (DFM) system for the treatment of severe aortic stenosis. Background The DFM transcatheter aortic valve system is a nonmetallic design with a pressurized support structure that allows precise positioning, retrieval, and assessment of valve performance prior to permanent implantation. Methods One hundred high surgical risk patients with severe aortic stenosis were evaluated for the primary endpoint. There were 75 patients in the group evaluable for the secondary endpoints and 25 in the pre-specified roll-in training phase. Echocardiographic and angiographic data were evaluated by an independent core laboratory and adverse events adjudicated by clinical event committee and classified according to Valve Academic Research Consortium (VARC) criteria. Results There was 99% freedom from all cause mortality at 30 days (primary endpoint). VARC criteria defined 30 day combined freedom from patient safety event rate was 91% and overall device success was 93%. The post-implantation echocardiography results demonstrated mild or no aortic regurgitation in 99% (73 of 74) with a mean gradient of 12.6 ± 7.1 mm Hg (n = 72) and effective orifice area of 1.50 ± 0.56 cm2 and New York Heart Association functional class was I or II in 92% of cases. Conclusions The present study demonstrates the safety and efficacy of the DFM system in surgical high risk patients with severe aortic stenosis and complex anatomy aortic regurgitation was less than moderate in 99% of patients.
Affiliations:
- Allemagne, France, Italie, Royaume-Uni, États-Unis
- Angleterre, Californie, District de Cologne, District de Columbia, Grand Londres, Hambourg, Illinois, Lombardie, Midi-Pyrénées, Occitanie (région administrative), Rhénanie-du-Nord-Westphalie
- Bonn, Hambourg, Londres, Milan, Toulouse
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Schmoeckel</name><affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Northwestern Memorial Hospital</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Davidson, Charles" sort="Davidson, Charles" uniqKey="Davidson C" first="Charles" last="Davidson">Charles Davidson</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>L'Institut Cardiovasculaire Paris Sud, L'Institut Hospitalier Jacques Cartier</s1><s2>Massy</s2><s3>FRA</s3><sZ>25 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Massy</wicri:noRegion><wicri:noRegion>L'Institut Hospitalier Jacques Cartier</wicri:noRegion><wicri:noRegion>Massy</wicri:noRegion></affiliation></author><author><name sortKey="Lefevre, Thierry" sort="Lefevre, Thierry" uniqKey="Lefevre T" first="Thierry" last="Lefevre">Thierry Lefevre</name><affiliation wicri:level="2"><inist:fA14 i1="14"><s1>Clinical Imaging Analytics</s1><s2>Guerneville, California</s2><s3>USA</s3><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">14-0086299</idno><date when="2014">2014</date><idno type="stanalyst">PASCAL 14-0086299 INIST</idno><idno type="RBID">Pascal:14-0086299</idno><idno type="wicri:Area/PascalFrancis/Corpus">000077</idno><idno type="wicri:Area/PascalFrancis/Curation">000B84</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000022</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000022</idno><idno type="wicri:doubleKey">0735-1097:2014:Schofer J:prospective:multicenter:evaluation</idno><idno type="wicri:Area/Main/Merge">000428</idno><idno type="wicri:Area/Main/Curation">000427</idno><idno 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aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Klugmann, Silvio" sort="Klugmann, Silvio" uniqKey="Klugmann S" first="Silvio" last="Klugmann">Silvio Klugmann</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Azienda Ospedaliera Niguarda Ca Granda</s1><s2>Milan</s2><s3>ITA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Fajadet, Jean" sort="Fajadet, Jean" uniqKey="Fajadet J" first="Jean" last="Fajadet">Jean Fajadet</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Clinique Pasteur</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region 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type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Maisano, Francesco" sort="Maisano, Francesco" uniqKey="Maisano F" first="Francesco" last="Maisano">Francesco Maisano</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>San Raffaele Hospital</s1><s2>Milan</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Bruschi, Giuseppe" sort="Bruschi, Giuseppe" uniqKey="Bruschi G" first="Giuseppe" last="Bruschi">Giuseppe Bruschi</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Azienda Ospedaliera Niguarda Ca Granda</s1><s2>Milan</s2><s3>ITA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Latib, Azeem" sort="Latib, Azeem" uniqKey="Latib A" first="Azeem" last="Latib">Azeem Latib</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>San Raffaele Hospital</s1><s2>Milan</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Bijuklic, Klaudija" sort="Bijuklic, Klaudija" uniqKey="Bijuklic K" first="Klaudija" last="Bijuklic">Klaudija Bijuklic</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Medical Care Center Prof. Mathey, Prof. Schofer, Hamburg University Cardiovascular Center</s1><s2>Hamburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Weissman, Neil" sort="Weissman, Neil" uniqKey="Weissman N" first="Neil" last="Weissman">Neil Weissman</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>MedStar Health Research Institute, Georgetown University</s1><s2>Washington, DC</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Low, Reginald" sort="Low, Reginald" uniqKey="Low R" first="Reginald" last="Low">Reginald Low</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>University of California Davis</s1><s2>Davis, California</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>St. Thomas' Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Thomas, Martyn" sort="Thomas, Martyn" uniqKey="Thomas M" first="Martyn" last="Thomas">Martyn Thomas</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>The Heart Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Young, Christopher" sort="Young, Christopher" uniqKey="Young C" first="Christopher" last="Young">Christopher Young</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>The Heart Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Redwood, Simon" sort="Redwood, Simon" uniqKey="Redwood S" first="Simon" last="Redwood">Simon Redwood</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>The Heart Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mullen, Michael" sort="Mullen, Michael" uniqKey="Mullen M" first="Michael" last="Mullen">Michael Mullen</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>University Hospital Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Yap, John" sort="Yap, John" uniqKey="Yap J" first="John" last="Yap">John Yap</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>University Hospital Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Grube, Eberhard" sort="Grube, Eberhard" uniqKey="Grube E" first="Eberhard" last="Grube">Eberhard Grube</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Krankenhaus der Barmherzigen</s1><s2>Trier</s2><s3>DEU</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Krankenhaus der Barmherzigen</wicri:noRegion><wicri:noRegion>Krankenhaus der Barmherzigen</wicri:noRegion></affiliation></author><author><name sortKey="Nickenig, Georg" sort="Nickenig, Georg" uniqKey="Nickenig G" first="Georg" last="Nickenig">Georg Nickenig</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Krankenhaus der Barmherzigen</s1><s2>Trier</s2><s3>DEU</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Krankenhaus der Barmherzigen</wicri:noRegion><wicri:noRegion>Krankenhaus der Barmherzigen</wicri:noRegion></affiliation></author><author><name sortKey="Sinning, Jan Malte" sort="Sinning, Jan Malte" uniqKey="Sinning J" first="Jan-Malte" last="Sinning">Jan-Malte Sinning</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Krankenhaus der Barmherzigen</s1><s2>Trier</s2><s3>DEU</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Krankenhaus der Barmherzigen</wicri:noRegion><wicri:noRegion>Krankenhaus der Barmherzigen</wicri:noRegion></affiliation></author><author><name sortKey="Hauptmann, Karl Eugen" sort="Hauptmann, Karl Eugen" uniqKey="Hauptmann K" first="Karl Eugen" last="Hauptmann">Karl Eugen Hauptmann</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Asklepios Klinik St Georg</s1><s2>Hamburg</s2><s3>DEU</s3><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Friedrich, Ivar" sort="Friedrich, Ivar" uniqKey="Friedrich I" first="Ivar" last="Friedrich">Ivar Friedrich</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Asklepios Klinik St Georg</s1><s2>Hamburg</s2><s3>DEU</s3><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Lauterbach, Michael" sort="Lauterbach, Michael" uniqKey="Lauterbach M" first="Michael" last="Lauterbach">Michael Lauterbach</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Asklepios Klinik St Georg</s1><s2>Hamburg</s2><s3>DEU</s3><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Schmoeckel, Michael" sort="Schmoeckel, Michael" uniqKey="Schmoeckel M" first="Michael" last="Schmoeckel">Michael Schmoeckel</name><affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Northwestern Memorial Hospital</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Davidson, Charles" sort="Davidson, Charles" uniqKey="Davidson C" first="Charles" last="Davidson">Charles Davidson</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>L'Institut Cardiovasculaire Paris Sud, L'Institut Hospitalier Jacques Cartier</s1><s2>Massy</s2><s3>FRA</s3><sZ>25 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Massy</wicri:noRegion><wicri:noRegion>L'Institut Hospitalier Jacques Cartier</wicri:noRegion><wicri:noRegion>Massy</wicri:noRegion></affiliation></author><author><name sortKey="Lefevre, Thierry" sort="Lefevre, Thierry" uniqKey="Lefevre T" first="Thierry" last="Lefevre">Thierry Lefevre</name><affiliation wicri:level="2"><inist:fA14 i1="14"><s1>Clinical Imaging Analytics</s1><s2>Guerneville, California</s2><s3>USA</s3><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Journal of the American College of Cardiology</title><title level="j" type="abbreviated">J. Am. Coll. Cardiol.</title><idno type="ISSN">0735-1097</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of the American College of Cardiology</title><title level="j" type="abbreviated">J. Am. Coll. Cardiol.</title><idno type="ISSN">0735-1097</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aortic valve</term><term>Cardiology</term><term>Cardiovascular disease</term><term>Circulatory system</term><term>Evaluation</term><term>Medicine</term><term>Multicenter study</term><term>Prospective</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie de l'appareil circulatoire</term><term>Prospective</term><term>Etude multicentrique</term><term>Evaluation</term><term>Médecine</term><term>Valvule aortique</term><term>Appareil circulatoire</term><term>Cardiologie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Prospective</term><term>Médecine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objectives The study sought a prospective multicenter nonrandomized evaluation of the Direct Flow Medical (DFM) system for the treatment of severe aortic stenosis. Background The DFM transcatheter aortic valve system is a nonmetallic design with a pressurized support structure that allows precise positioning, retrieval, and assessment of valve performance prior to permanent implantation. Methods One hundred high surgical risk patients with severe aortic stenosis were evaluated for the primary endpoint. There were 75 patients in the group evaluable for the secondary endpoints and 25 in the pre-specified roll-in training phase. Echocardiographic and angiographic data were evaluated by an independent core laboratory and adverse events adjudicated by clinical event committee and classified according to Valve Academic Research Consortium (VARC) criteria. Results There was 99% freedom from all cause mortality at 30 days (primary endpoint). VARC criteria defined 30 day combined freedom from patient safety event rate was 91% and overall device success was 93%. The post-implantation echocardiography results demonstrated mild or no aortic regurgitation in 99% (73 of 74) with a mean gradient of 12.6 ± 7.1 mm Hg (n = 72) and effective orifice area of 1.50 ± 0.56 cm<sup>2</sup> and New York Heart Association functional class was I or II in 92% of cases. Conclusions The present study demonstrates the safety and efficacy of the DFM system in surgical high risk patients with severe aortic stenosis and complex anatomy aortic regurgitation was less than moderate in 99% of patients.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>France</li><li>Italie</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>District de Cologne</li><li>District de Columbia</li><li>Grand Londres</li><li>Hambourg</li><li>Illinois</li><li>Lombardie</li><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Bonn</li><li>Hambourg</li><li>Londres</li><li>Milan</li><li>Toulouse</li></settlement></list><tree><country name="Allemagne"><region name="Hambourg"><name sortKey="Schofer, Joachim" sort="Schofer, Joachim" uniqKey="Schofer J" first="Joachim" last="Schofer">Joachim Schofer</name></region><name sortKey="Bijuklic, Klaudija" sort="Bijuklic, Klaudija" uniqKey="Bijuklic K" first="Klaudija" last="Bijuklic">Klaudija Bijuklic</name><name sortKey="Friedrich, Ivar" sort="Friedrich, Ivar" uniqKey="Friedrich I" first="Ivar" last="Friedrich">Ivar Friedrich</name><name sortKey="Grube, Eberhard" sort="Grube, Eberhard" uniqKey="Grube E" first="Eberhard" last="Grube">Eberhard Grube</name><name sortKey="Hauptmann, Karl Eugen" sort="Hauptmann, Karl Eugen" uniqKey="Hauptmann K" first="Karl Eugen" last="Hauptmann">Karl Eugen Hauptmann</name><name sortKey="Lauterbach, Michael" sort="Lauterbach, Michael" uniqKey="Lauterbach M" first="Michael" last="Lauterbach">Michael Lauterbach</name><name sortKey="Mullen, Michael" sort="Mullen, Michael" uniqKey="Mullen M" first="Michael" last="Mullen">Michael Mullen</name><name sortKey="Nickenig, Georg" sort="Nickenig, Georg" uniqKey="Nickenig G" first="Georg" last="Nickenig">Georg Nickenig</name><name sortKey="Sinning, Jan Malte" sort="Sinning, Jan Malte" uniqKey="Sinning J" first="Jan-Malte" last="Sinning">Jan-Malte Sinning</name><name sortKey="Yap, John" sort="Yap, John" uniqKey="Yap J" first="John" last="Yap">John Yap</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Colombo, Antonio" sort="Colombo, Antonio" uniqKey="Colombo A" first="Antonio" last="Colombo">Antonio Colombo</name></region><name sortKey="Bruschi, Giuseppe" sort="Bruschi, Giuseppe" uniqKey="Bruschi G" first="Giuseppe" last="Bruschi">Giuseppe Bruschi</name><name sortKey="Demarco, Federico" sort="Demarco, Federico" uniqKey="Demarco F" first="Federico" last="Demarco">Federico Demarco</name><name sortKey="Klugmann, Silvio" sort="Klugmann, Silvio" uniqKey="Klugmann S" first="Silvio" last="Klugmann">Silvio Klugmann</name><name sortKey="Latib, Azeem" sort="Latib, Azeem" uniqKey="Latib A" first="Azeem" last="Latib">Azeem Latib</name><name sortKey="Maisano, Francesco" sort="Maisano, Francesco" uniqKey="Maisano F" first="Francesco" last="Maisano">Francesco Maisano</name></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Fajadet, Jean" sort="Fajadet, Jean" uniqKey="Fajadet J" first="Jean" last="Fajadet">Jean Fajadet</name></region><name sortKey="Davidson, Charles" sort="Davidson, Charles" uniqKey="Davidson C" first="Charles" last="Davidson">Charles Davidson</name><name sortKey="Tchetche, Didier" sort="Tchetche, Didier" uniqKey="Tchetche D" first="Didier" last="Tchetche">Didier Tchetche</name></country><country name="États-Unis"><region name="District de Columbia"><name sortKey="Weissman, Neil" sort="Weissman, Neil" uniqKey="Weissman N" first="Neil" last="Weissman">Neil Weissman</name></region><name sortKey="Lefevre, Thierry" sort="Lefevre, Thierry" uniqKey="Lefevre T" first="Thierry" last="Lefevre">Thierry Lefevre</name><name sortKey="Low, Reginald" sort="Low, Reginald" uniqKey="Low R" first="Reginald" last="Low">Reginald Low</name><name sortKey="Schmoeckel, Michael" sort="Schmoeckel, Michael" uniqKey="Schmoeckel M" first="Michael" last="Schmoeckel">Michael Schmoeckel</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Low, Reginald" sort="Low, Reginald" uniqKey="Low R" first="Reginald" last="Low">Reginald Low</name></region><name sortKey="Redwood, Simon" sort="Redwood, Simon" uniqKey="Redwood S" first="Simon" last="Redwood">Simon Redwood</name><name sortKey="Thomas, Martyn" sort="Thomas, Martyn" uniqKey="Thomas M" first="Martyn" last="Thomas">Martyn Thomas</name><name sortKey="Young, Christopher" sort="Young, Christopher" uniqKey="Young C" first="Christopher" last="Young">Christopher Young</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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